Lyophilized Peptides
In their freeze-dried form, peptides are most stable. Sealed glass vials of lyophilized peptide are typically stored at −20 °C, protected from light and moisture. Under these conditions, many sequences remain stable for one to two years or longer; consult the COA for lot-specific guidance.
Avoiding Moisture
Allow vials to come to room temperature before opening. Cold glass condenses ambient moisture, which can hydrolyze sensitive sequences. Reseal promptly and return to the freezer.
Reconstituted Peptides
Once reconstituted in an aqueous diluent (such as bacteriostatic water), peptides are far less stable. Short-term storage at 2–8 °C is typical; longer-term storage at −20 °C or −80 °C in single-use aliquots avoids freeze-thaw cycles, which accelerate degradation.
Documenting Conditions
Good lab practice means logging storage conditions and aliquot dates. If a study extends over months, periodic re-characterization (e.g., a fresh HPLC run) confirms the material has not drifted. Refer to the lot's COA for the original purity baseline.
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